The P-51 was designed as the NA-73 in 1940 at Britain's request. The design showed promise, and AAF purchases of Allison-powered Mustangs began in 1941, primarily for photo recon and ground support use due to its limited high-altitude performance. But in 1942, tests of P-51s using the British Rolls-Royce "Merlin" engine revealed much improved speed and service ceiling, and in December 1943 Merlin-powered P-51Bs first entered combat over Europe. Providing high-altitude escort to B-17s and B-24s, they scored heavily over German interceptors, and by war's end, P-51s had destroyed 4,950 enemy aircraft in the air, more than any other fighter in Europe.

Mustangs served in nearly every combat zone, including the Pacific where they escorted B-29s to Japan from Iwo Jima. Between 1941 and 1945, the AAF ordered 14,855 Mustangs (including A-36A dive bomber and F-6 photo recon versions), of which 7,956 were P-51Ds. During the Korean War, P-51Ds were used primarily for close support of ground forces until withdrawn from combat in 1953.