On September 8, 1966, Star Trek premiered. Centered on the interstellar voyages of the U.S.S. Enterprise, the prime-time television program's mission was to boldly go where no man has gone before. With an intricate futuristic setting, multicultural cast, and story lines that touched on social issues, Star Trek pushed past the boundaries of popular science fiction and became a worldwide phenomenon.

Each of the 20 self-adhesive Star Trek stamps showcases one of four digital illustrations inspired by elements of the classic TV show: the Starship Enterprise inside the outline of a Starfleet insignia against a gold background, the silhouette of a crewman in a transporter against a red background, the silhouette of the Enterprise from above against a green background, and the Enterprise inside the outline of the Vulcan salute (Spock's iconic hand gesture) against a blue background. The stamp sheet includes five of each design. The words FOREVER USA, separated by a small Starfleet insignia, appear along the top edge or the bottom edge of each stamp. The words SPACE... THE FINAL FRONTIER, from Captain Kirk's famous voice-over, appear beneath the stamps against a background of stars.