North Carolina's most famous and perhaps greatest writer, Thomas Wolfe, was born in Asheville, the eighth child of a Pennsylvania stonecutter and his third wife, a hill country school teacher. Wolfe grew up in his mother's boarding house. An exceptional student, he started public school before he was six, and at age eleven transferred at his teachers' request to a private school. He entered the university at Chapel Hill at 15 "an awkward, unhappy misfit." By the time he graduated, he was editor of the college newspaper and had seen several of his plays produced by the Carolina Playmakers.

Planning to become a dramatist, he went to Harvard, then to New York, where no one would produce his very long plays. To "buy time," he took a job teaching at New York University. During a 1926 trip to Europe, he began writing down his early memories of Asheville. He abandoned playwriting, and after three years of writing, revision and editing, published Look Homeward, Angel: A Story of the Buried Life. Look Homeward, Angel, considered one of the great coming-of-age novels in the English language, follows the story of Eugene Gant, a sensitive, intelligent boy growing up in a small Southern mountain city. The book's success allowed Wolfe to leave his teaching job to travel and continue writing.

Six years later, Wolfe published Of Time and the River, which continues Eugene's adventures as a young man at Harvard, and in New York and Europe. Wolfe divided the next three years between writing and travelling in the United States and Europe. In 1938, he turned his mountainous manuscript over to Edward C. Aswell, his editor at Harper & Brothers, and left for the West Coast. While in Seattle, he was taken ill with pneumonia. He was brought across the continent for surgery at Johns Hopkins, in Baltimore, where he died of miliary tuberculosis of the brain.