The Lower Keys rabbit is the smallest of three subspecies of marsh rabbits.  This species can reach a length of 14-16 inches long (3.5-4 centimeters).  This species has a brown dorsal (back); gray belly, small ears, and a grayish-brown tail.

Lower Keys rabbits inhabit higher elevation levels around fresh and salt water marshes. This species is endemic to the Florida Keys from Big Pine Key to Boca Chica Key.

The main threats to the Lower Keys rabbit is habitat destruction and fragmentation.  Habitat destruction has been extensive in the Florida Keys, and the rabbit has lost 50% of its habitat in the last 25 years (Faulhaber and Smith 2008).  Human development has increased along the coast and islands, which destroys habitats that were once uninterrupted.  Habitat fragmentation is also a threat with increased development, as the habitat is broken off into different sections, segregating populations.  Small segregated populations can be difficult to sustain, leading to extirpation.  Invasive vegetation decreases available food for the rabbit by out-competing the native vegetation that rabbits feed on.  Rabbits are also threatened by sea level rise from global climate change.  As ground nesters, a dramatic rise in sea level would inundate their habitat and nesting areas.  Hurricanes pose a threat as the accompanying storm surge can also inundate their habitat and nesting area.  Other threats include predation from domesticated and feral cats, hits from cars, and illegal poaching.